Ontology highlight
ABSTRACT:
SUBMITTER: Mukku N
PROVIDER: S-EPMC7643254 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
ACS omega 20201020 43
In this study, a highly efficient two-component [3 + 2] cycloaddition reaction of substituted aryl aldehydes with 4-toluenesulfonylmethyl isocyanide (TosMIC) in the presence of 2 equiv of potassium phosphate as a base to 5-substituted oxazoles were established in a isopropanol medium under microwave irradiation. However, using 1 equiv of K<sub>3</sub>PO<sub>4</sub> as a base resulted in the diastereoselective synthesis of 4,5-disubstituted oxazolines under identical reaction conditions. The fore ...[more]