Ontology highlight
ABSTRACT:
SUBMITTER: Subramaniam A
PROVIDER: S-EPMC7645986 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Subramaniam Agatheeswaran A Žemaitis Kristijonas K Talkhoncheh Mehrnaz Safaee MS Yudovich David D Bäckström Alexandra A Debnath Shubhranshu S Chen Jun J Jain Mayur Vilas MV Galeev Roman R Gaetani Massimiliano M Zubarev Roman A RA Larsson Jonas J
Blood 20201101 19
Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. Here, we report that inhibition of the epigenetic regulator lysine-specific histone demethylase 1A (LSD1) induces a rapid expansion of human cord blood-derived CD34+ cells and promotes in vitro propagation of long-term repopulating HSCs by preventing differentiation. The phenotype and molecular characteristics of cells treated with LSD1 inhibitors were highly similar to cells ...[more]