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Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children.

ABSTRACT: OBJECTIVE:Evaluate the performance of QuantiFERON ® -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children. METHOD:Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of QFT-GIT were assessed in 58/63 HIV-infected children who were suspected of having TB. RESULTS:Sensitivity of QFT-GIT was 20.69%, specificity 96.55%, PPV/NPV respectively 85.71% and 54.90%. CONCLUSION:QFT-GIT appears to be of little contribution to the diagnosis of active TB in children living with HIV in a TB-endemic country.

SUBMITTER: Sanogo B 

PROVIDER: S-EPMC7647084 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children.

Sanogo Bintou B   Ouermi Alain Saga AS   Barro Makoura M   Millogo Anselme A   Ouattara Ad Bafa Ibrahim ABI   Abdoul Salam Ouédraogo O   Nacro Boubacar B  

PloS one 20201106 11

<h4>Objective</h4>Evaluate the performance of QuantiFERON ® -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children.<h4>Method</h4>Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of QFT-GIT were assessed in 58/63 HIV-infected children who were suspected of having TB.<h4>Results</h4>Sensitivity of QFT-GIT was 20.69%, specificity 96.55%, PPV/NPV respectively 85.71% and  ...[more]

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