Dataset Information

Transmissibility of coronavirus disease 2019 in Chinese cities with different dynamics of imported cases.

ABSTRACT:

Background

Monitoring the reproduction number (R_t ) of the disease could help determine whether there is sustained transmission in a population, but areas with similar epidemic trends could have different transmission dynamics given the risk from imported cases varied across regions. In this study, we examined the R_t of coronavirus disease 2019 (COVID-19) by taking different dynamics of imported cases into account and compared the transmissibility of COVID-19 at different intervention periods in Hangzhou and Shenzhen.

Methods

We obtained the daily aggregated counts of laboratory-confirmed imported and local cases of COVID-19 infections in Hangzhou and Shenzhen from January 1 to March 13, 2020. Daily R_t and piecewise R_t before and after Wuhan lockdown were estimated, accounting for imported cases.

Results

Since the epidemic of COVID-19 in Shenzhen was dominated by imported cases, R_t was around 0.1 to 0.7 before the Wuhan lockdown. After the lockdown of Wuhan and the initialization of measures in response to the outbreak, local transmission was well-controlled as indicated by a low estimated value of piecewise R_t , 0.15 (95% CI [0.09-0.21]). On the contrary, R_t obtained for Hangzhou ranged from 1.2 to 4.9 with a piecewise R_t of 2.55 (95% CI [2.13-2.97]) before the lockdown of Wuhan due to the surge in local cases. Because of the Wuhan lockdown and other outbreak response measures, R_t dropped below unity in mid-February.

Conclusions

Even though Shenzhen had more cases than Hangzhou, local transmission did not sustain probably due to limited transmission from imported cases owing to the reduction in local susceptibles as residents left the city during Chunyun. The lockdown measures and local outbreak responses helped reduce the local transmissibility.

SUBMITTER: Chong KC

PROVIDER: S-EPMC7651459 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Transmissibility of coronavirus disease 2019 in Chinese cities with different dynamics of imported cases.

Chong Ka Chun KC Cheng Wei W Zhao Shi S Ling Feng F Mohammad Kirran N KN Wang Maggie M Zee Benny Cy BC Wei Lai L Xiong Xi X Liu Hengyan H Wang Jingxuan J Chen Enfu E

PeerJ 20201106

<h4>Background</h4>Monitoring the reproduction number (<i>R<sub>t</sub></i> ) of the disease could help determine whether there is sustained transmission in a population, but areas with similar epidemic trends could have different transmission dynamics given the risk from imported cases varied across regions. In this study, we examined the <i>R<sub>t</sub></i> of coronavirus disease 2019 (COVID-19) by taking different dynamics of imported cases into account and compared the transmissibility of C ...[more]

PMID: 33194456

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Project description:BackgroundThe coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2, is a global public health emergency. Data on the effect of coronavirus disease 2019 in pregnancy are limited to small case series.ObjectiveTo evaluate the clinical characteristics and outcomes in pregnancy and the vertical transmission potential of severe acute respiratory syndrome coronavirus 2 infection.Study designClinical records were retrospectively reviewed for 116 pregnant women with coronavirus disease 2019 pneumonia from 25 hospitals in China between January 20, 2020, and March 24, 2020. Evidence of vertical transmission was assessed by testing for severe acute respiratory syndrome coronavirus 2 in amniotic fluid, cord blood, and neonatal pharyngeal swab samples.ResultsThe median gestational age on admission was 38+0 (interquartile range, 36+0-39+1) weeks. The most common symptoms were fever (50.9%, 59/116) and cough (28.4%, 33/116); 23.3% (27/116) patients presented without symptoms. Abnormal radiologic findings were found in 96.3% (104/108) of cases. Of the 116 cases, there were 8 cases (6.9%) of severe pneumonia but no maternal deaths. One of 8 patients who presented in the first trimester and early second trimester had a missed spontaneous abortion. Of 99 patients, 21 (21.2%) who delivered had preterm birth, including 6 with preterm premature rupture of membranes. The rate of spontaneous preterm birth before 37 weeks' gestation was 6.1% (6/99). One case of severe neonatal asphyxia resulted in neonatal death. Furthermore, 86 of the 100 neonates tested for severe acute respiratory syndrome coronavirus 2 had negative results; of these, paired amniotic fluid and cord blood samples from 10 neonates used to test for severe acute respiratory syndrome coronavirus 2 had negative results.ConclusionSevere acute respiratory syndrome coronavirus 2 infection during pregnancy is not associated with an increased risk of spontaneous abortion and spontaneous preterm birth. There is no evidence of vertical transmission of severe acute respiratory syndrome coronavirus 2 infection when the infection manifests during the third trimester of pregnancy.

Dataset Information

Transmissibility of coronavirus disease 2019 in Chinese cities with different dynamics of imported cases.

Background

Methods

Results

Conclusions

Publications

Transmissibility of coronavirus disease 2019 in Chinese cities with different dynamics of imported cases.

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