Ontology highlight
ABSTRACT:
SUBMITTER: Wu XR
PROVIDER: S-EPMC7653962 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Wu Xin-Rong XR Zhang Yu Y Liu Xian-Dong XD Han Wu-Bo WB Xu Nan-Jie NJ Sun Suya S
Translational psychiatry 20201109 1
Social isolation in adolescence leads to lasting deficits, including emotional and cognitive dysregulation. It remains unclear, however, how social isolation affects certain processes of memory and what molecular mechanisms are involved. In this study, we found that social isolation during the post-weaning period resulted in forgetting of the long-term fear memory, which was attributable to the downregulation of synaptic function in the hippocampal CA1 region mediated by EphB2, a receptor tyrosi ...[more]