Ontology highlight
ABSTRACT: Background
Prevalence of IgG antibodies against SARS-CoV-2 infection provides essential information for deciding disease prevention and mitigation measures. We estimate the seroprevalence of SARS-CoV-2 specific IgG antibodies in District Srinagar.Methods
2906 persons >18 years of age selected from hospital visitors across District Srinagar participated in the study. We tested samples for the presence of SARS-CoV-2 specific IgG antibodies using a chemiluminescent microparticle immunoassay-based serologic test.Results
Age- and gender-standardized seroprevalence was 3.6% (95% CI 2.9% to 4.3%). Age 30-69 years, a recent history of symptoms of an influenza-like-illness, and a history of being placed under quarantine were significantly related to higher odds of the presence of SARS-CoV-2 specific IgG antibodies. The estimated number of SARS-CoV-2 infections during the two weeks preceding the study, adjusted for test performance, was 32602 with an estimated (median) infection-to-known-case ratio of 46 (95% CI 36 to 57).Conclusions
The seroprevalence of SARS-CoV-2 specific IgG antibodies is low in the District. A large proportion of the population is still susceptible to the infection. A sizeable number of infections remain undetected, and a substantial proportion of people with symptoms compatible with COVID-19 are not tested.
SUBMITTER: Khan SMS
PROVIDER: S-EPMC7657487 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Khan S Muhammad Salim SMS Qurieshi Mariya Amin MA Haq Inaamul I Majid Sabhiya S Bhat Arif Akbar AA Nabi Sahila S Ganai Nisar Ahmad NA Zahoor Nazia N Nisar Auqfeen A Chowdri Iqra Nisar IN Qazi Tanzeela Bashir TB Kousar Rafiya R Lone Abdul Aziz AA Sabah Iram I Nabi Shahroz S Sumji Ishtiyaq Ahmad IA Kawoosa Misbah Ferooz MF Ayoub Shifana S
PloS one 20201111 11
<h4>Background</h4>Prevalence of IgG antibodies against SARS-CoV-2 infection provides essential information for deciding disease prevention and mitigation measures. We estimate the seroprevalence of SARS-CoV-2 specific IgG antibodies in District Srinagar.<h4>Methods</h4>2906 persons >18 years of age selected from hospital visitors across District Srinagar participated in the study. We tested samples for the presence of SARS-CoV-2 specific IgG antibodies using a chemiluminescent microparticle imm ...[more]