Ontology highlight
ABSTRACT:
SUBMITTER: Bekbolsynov D
PROVIDER: S-EPMC7659444 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Bekbolsynov Dulat D Mierzejewska Beata B Borucka Jadwiga J Liwski Robert S RS Greenshields Anna L AL Breidenbach Joshua J Gehring Bradley B Leonard-Murali Shravan S Khuder Sadik A SA Rees Michael M Green Robert C RC Stepkowski Stanislaw M SM
Frontiers in immunology 20201029
We evaluated the impact of human leukocyte antigen (HLA) disparity (immunogenicity; IM) on long-term kidney allograft survival. The IM was quantified based on physicochemical properties of the polymorphic linear donor/recipient HLA amino acids (the Cambridge algorithm) as a hydrophobic, electrostatic, amino acid mismatch scores (HMS\AMS\EMS) or eplet mismatch (EpMM) load. High-resolution HLA-A/B/DRB1/DQB1 types were imputed to calculate HMS for primary/re-transplant recipients of deceased donor ...[more]