Ontology highlight
ABSTRACT:
SUBMITTER: Richaud AD
PROVIDER: S-EPMC7659681 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Richaud Alexis D AD Roche Stéphane P SP
The Journal of organic chemistry 20200917 19
The design of novel and functional biomimetic foldamers remains a major challenge in creating mimics of native protein structures. Herein, we report the stabilization of a remarkably short β-sheet by incorporating <i>N</i>-(hydroxy)glycine (Hyg) residues into the backbone of peptides. These peptide-peptoid hybrids form unique parallel β-sheet structures by self-assembly upon hydrogenation. Our spectroscopic and crystallographic data suggest that the local conformational perturbations induced by ...[more]