Ontology highlight
ABSTRACT:
SUBMITTER: Wang M
PROVIDER: S-EPMC6269506 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Wang Meng M Wang Jiqian J Zhou Peng P Deng Jing J Zhao Yurong Y Sun Yawei Y Yang Wei W Wang Dong D Li Zongyi Z Hu Xuzhi X King Stephen M SM Rogers Sarah E SE Cox Henry H Waigh Thomas A TA Yang Jun J Lu Jian Ren JR Xu Hai H
Nature communications 20181130 1
Peptide self-assembly is a hierarchical process, often starting with the formation of α-helices, β-sheets or β-hairpins. However, how the secondary structures undergo further assembly to form higher-order architectures remains largely unexplored. The polar zipper originally proposed by Perutz is formed between neighboring β-strands of poly-glutamine via their side-chain hydrogen bonding and helps to stabilize the sheet. By rational design of short amphiphilic peptides and their self-assembly, he ...[more]