Ontology highlight
ABSTRACT:
SUBMITTER: Jovine L
PROVIDER: S-EPMC395899 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Jovine Luca L Qi Huayu H Williams Zev Z Litscher Eveline S ES Wassarman Paul M PM
Proceedings of the National Academy of Sciences of the United States of America 20040412 16
Many secreted eukaryotic glycoproteins that play fundamental roles in development, hearing, immunity, and cancer polymerize into filaments and extracellular matrices through zona pellucida (ZP) domains. ZP domain proteins are synthesized as precursors containing C-terminal propeptides that are cleaved at conserved sites. However, the consequences of this processing and the mechanism by which nascent proteins assemble are unclear. By microinjection of mutated DNA constructs into growing oocytes a ...[more]