Ontology highlight
ABSTRACT:
SUBMITTER: Gavande NS
PROVIDER: S-EPMC7672428 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Gavande Navnath S NS VanderVere-Carozza Pamela S PS Pawelczak Katherine S KS Mendoza-Munoz Pamela P Vernon Tyler L TL Hanakahi Leslyn A LA Summerlin Matthew M Dynlacht Joseph R JR Farmer Annabelle H AH Sears Catherine R CR Nasrallah Nawar Al NA Garrett Joy J Turchi John J JJ
Nucleic acids research 20201101 20
DNA-dependent protein kinase (DNA-PK) plays a critical role in the non-homologous end joining (NHEJ) repair pathway and the DNA damage response (DDR). DNA-PK has therefore been pursued for the development of anti-cancer therapeutics in combination with ionizing radiation (IR). We report the discovery of a new class of DNA-PK inhibitors that act via a novel mechanism of action, inhibition of the Ku-DNA interaction. We have developed a series of highly potent and specific Ku-DNA binding inhibitors ...[more]