Ontology highlight
ABSTRACT:
SUBMITTER: Quilty F
PROVIDER: S-EPMC7672620 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Quilty Fran F Byrne Anne-Marie AM Aird John J El Mashad Sheeren S Parra-Blanco Adolfo A Long Aideen A Gilmer John F JF Medina Carlos C
International journal of molecular sciences 20201028 21
Bile acids (BAs) have been implicated in the development of oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma (OAC). However, whether BAs promote cancer invasiveness has not been elucidated. We evaluated the role of BAs, in particular deoxycholic acid (DCA), in OAC invasion. Migration and invasiveness in untreated and BA-treated oesophageal SKGT-4 cancer cells were evaluated. Activity and expression of different matrix metalloproteinases (MMPs) were determined by zymography, ELIS ...[more]