Ontology highlight
ABSTRACT:
SUBMITTER: Kintaka R
PROVIDER: S-EPMC7673788 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Kintaka Reiko R Makanae Koji K Namba Shotaro S Kato Hisaaki H Kito Keiji K Ohnuki Shinsuke S Ohya Yoshikazu Y Andrews Brenda J BJ Boone Charles C Moriya Hisao H
eLife 20201104
Overproduction (op) of proteins triggers cellular defects. One of the consequences of overproduction is the protein burden/cost, which is produced by an overloading of the protein synthesis process. However, the physiology of cells under a protein burden is not well characterized. We performed genetic profiling of protein burden by systematic analysis of genetic interactions between GFP-op, surveying both deletion and temperature-sensitive mutants in budding yeast. We also performed genetic prof ...[more]