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Competitive performance of a modularized deep neural network compared to commercial algorithms for low-dose CT image reconstruction.

ABSTRACT: Commercial iterative reconstruction techniques help to reduce CT radiation dose but altered image appearance and artifacts limit their adoptability and potential use. Deep learning has been investigated for low-dose CT (LDCT). Here we design a modularized neural network for LDCT and compared it with commercial iterative reconstruction methods from three leading CT vendors. While popular networks are trained for an end-to-end mapping, our network performs an end-to-process mapping so that intermediate denoised images are obtained with associated noise reduction directions towards a final denoised image. The learned workflow allows radiologists-in-the-loop to optimize the denoising depth in a task-specific fashion. Our network was trained with the Mayo LDCT Dataset, and tested on separate chest and abdominal CT exams from Massachusetts General Hospital. The best deep learning reconstructions were systematically compared to the best iterative reconstructions in a double-blinded reader study. This study confirms that our deep learning approach performed either favorably or comparably in terms of noise suppression and structural fidelity, and is much faster than the commercial iterative reconstruction algorithms.

SUBMITTER: Shan H

PROVIDER: S-EPMC7687920 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Competitive performance of a modularized deep neural network compared to commercial algorithms for low-dose CT image reconstruction.

Shan Hongming H Padole Atul A Homayounieh Fatemeh F Kruger Uwe U Khera Ruhani Doda RD Nitiwarangkul Chayanin C Kalra Mannudeep K MK Wang Ge G

Nature machine intelligence 20190610 6

Commercial iterative reconstruction techniques help to reduce CT radiation dose but altered image appearance and artifacts limit their adoptability and potential use. Deep learning has been investigated for low-dose CT (LDCT). Here we design a modularized neural network for LDCT and compared it with commercial iterative reconstruction methods from three leading CT vendors. While popular networks are trained for an end-to-end mapping, our network performs an end-to-process mapping so that interme ...[more]

PMID: 33244514

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Project description:ObjectivesTo evaluate image quality and reconstruction times of a commercial deep learning reconstruction algorithm (DLR) compared to hybrid-iterative reconstruction (Hybrid-IR) and model-based iterative reconstruction (MBIR) algorithms for cerebral non-contrast CT (NCCT).MethodsCerebral NCCT acquisitions of 50 consecutive patients were reconstructed using DLR, Hybrid-IR and MBIR with a clinical CT system. Image quality, in terms of six subjective characteristics (noise, sharpness, grey-white matter differentiation, artefacts, natural appearance and overall image quality), was scored by five observers. As objective metrics of image quality, the noise magnitude and signal-difference-to-noise ratio (SDNR) of the grey and white matter were calculated. Mean values for the image quality characteristics scored by the observers were estimated using a general linear model to account for multiple readers. The estimated means for the reconstruction methods were pairwise compared. Calculated measures were compared using paired t tests.ResultsFor all image quality characteristics, DLR images were scored significantly higher than MBIR images. Compared to Hybrid-IR, perceived noise and grey-white matter differentiation were better with DLR, while no difference was detected for other image quality characteristics. Noise magnitude was lower for DLR compared to Hybrid-IR and MBIR (5.6, 6.4 and 6.2, respectively) and SDNR higher (2.4, 1.9 and 2.0, respectively). Reconstruction times were 27 s, 44 s and 176 s for Hybrid-IR, DLR and MBIR respectively.ConclusionsWith a slight increase in reconstruction time, DLR results in lower noise and improved tissue differentiation compared to Hybrid-IR. Image quality of MBIR is significantly lower compared to DLR with much longer reconstruction times.Key points• Deep learning reconstruction of cerebral non-contrast CT results in lower noise and improved tissue differentiation compared to hybrid-iterative reconstruction. • Deep learning reconstruction of cerebral non-contrast CT results in better image quality in all aspects evaluated compared to model-based iterative reconstruction. • Deep learning reconstruction only needs a slight increase in reconstruction time compared to hybrid-iterative reconstruction, while model-based iterative reconstruction requires considerably longer processing time.

Project description:ObjectiveFew studies have explored the clinical feasibility of using deep-learning reconstruction to reduce the radiation dose of CT. We aimed to compare the image quality and lung nodule detectability between chest CT using a quarter of the low dose (QLD) reconstructed with vendor-agnostic deep-learning image reconstruction (DLIR) and conventional low-dose (LD) CT reconstructed with iterative reconstruction (IR).Materials and methodsWe retrospectively collected 100 patients (median age, 61 years [IQR, 53-70 years]) who received LDCT using a dual-source scanner, where total radiation was split into a 1:3 ratio. QLD CT was generated using a quarter dose and reconstructed with DLIR (QLD-DLIR), while LDCT images were generated using a full dose and reconstructed with IR (LD-IR). Three thoracic radiologists reviewed subjective noise, spatial resolution, and overall image quality, and image noise was measured in five areas. The radiologists were also asked to detect all Lung-RADS category 3 or 4 nodules, and their performance was evaluated using area under the jackknife free-response receiver operating characteristic curve (AUFROC).ResultsThe median effective dose was 0.16 (IQR, 0.14-0.18) mSv for QLD CT and 0.65 (IQR, 0.57-0.71) mSv for LDCT. The radiologists' evaluations showed no significant differences in subjective noise (QLD-DLIR vs. LD-IR, lung-window setting; 3.23 ± 0.19 vs. 3.27 ± 0.22; P = .11), spatial resolution (3.14 ± 0.28 vs. 3.16 ± 0.27; P = .12), and overall image quality (3.14 ± 0.21 vs. 3.17 ± 0.17; P = .15). QLD-DLIR demonstrated lower measured noise than LD-IR in most areas (P < .001 for all). No significant difference was found between QLD-DLIR and LD-IR for the sensitivity (76.4% vs. 72.2%; P = .35) or the AUFROCs (0.77 vs. 0.78; P = .68) in detecting Lung-RADS category 3 or 4 nodules. Under a noninferiority limit of -0.1, QLD-DLIR showed noninferior detection performance (95% CI for AUFROC difference, -0.04 to 0.06).ConclusionQLD-DLIR images showed comparable image quality and noninferior nodule detectability relative to LD-IR images.

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Competitive performance of a modularized deep neural network compared to commercial algorithms for low-dose CT image reconstruction.

Publications

Competitive performance of a modularized deep neural network compared to commercial algorithms for low-dose CT image reconstruction.

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