Label-free X-ray estimation of brain amyloid burden.
Ontology highlight
ABSTRACT:
SUBMITTER: Dahal E
PROVIDER: S-EPMC7689528 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Label-free X-ray estimation of brain amyloid burden.
Dahal Eshan E Ghammraoui Bahaa B Ye Meijun M Smith J Carson JC Badano Aldo A
Scientific reports 20201125 1
Amyloid plaque deposits in the brain are indicative of Alzheimer's and other diseases. Measurements of brain amyloid burden in small animals require laborious post-mortem histological analysis or resource-intensive, contrast-enhanced imaging techniques. We describe a label-free method based on spectral small-angle X-ray scattering with a polychromatic beam for in vivo estimation of brain amyloid burden. Our findings comparing 5XFAD versus wild-type mice correlate well with histology, showing pro ...[more]
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