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The role of cortisol in ischemic heart disease, ischemic stroke, type 2 diabetes, and cardiovascular disease risk factors: a bi-directional Mendelian randomization study.


ABSTRACT: BACKGROUND:Cortisol, a steroid hormone frequently used as a biomarker of stress, is associated with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). To clarify whether cortisol causes these outcomes, we assessed the role of cortisol in ischemic heart disease (IHD), ischemic stroke, T2DM, and CVD risk factors using a bi-directional Mendelian randomization (MR) study. METHODS:Single nucleotide polymorphisms (SNPs) strongly (P?-6) and independently (r2?

SUBMITTER: Kwok MK 

PROVIDER: S-EPMC7694946 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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The role of cortisol in ischemic heart disease, ischemic stroke, type 2 diabetes, and cardiovascular disease risk factors: a bi-directional Mendelian randomization study.

Kwok Man Ki MK   Kawachi Ichiro I   Rehkopf David D   Schooling Catherine Mary CM  

BMC medicine 20201127 1


<h4>Background</h4>Cortisol, a steroid hormone frequently used as a biomarker of stress, is associated with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). To clarify whether cortisol causes these outcomes, we assessed the role of cortisol in ischemic heart disease (IHD), ischemic stroke, T2DM, and CVD risk factors using a bi-directional Mendelian randomization (MR) study.<h4>Methods</h4>Single nucleotide polymorphisms (SNPs) strongly (P < 5 × 10<sup>-6</sup>) and independently  ...[more]

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