The role of cortisol in ischemic heart disease, ischemic stroke, type 2 diabetes, and cardiovascular disease risk factors: a bi-directional Mendelian randomization study.
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ABSTRACT:
SUBMITTER: Kwok MK
PROVIDER: S-EPMC7694946 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
The role of cortisol in ischemic heart disease, ischemic stroke, type 2 diabetes, and cardiovascular disease risk factors: a bi-directional Mendelian randomization study.
Kwok Man Ki MK Kawachi Ichiro I Rehkopf David D Schooling Catherine Mary CM
BMC medicine 20201127 1
<h4>Background</h4>Cortisol, a steroid hormone frequently used as a biomarker of stress, is associated with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). To clarify whether cortisol causes these outcomes, we assessed the role of cortisol in ischemic heart disease (IHD), ischemic stroke, T2DM, and CVD risk factors using a bi-directional Mendelian randomization (MR) study.<h4>Methods</h4>Single nucleotide polymorphisms (SNPs) strongly (P < 5 × 10<sup>-6</sup>) and independently ...[more]
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