Ontology highlight
ABSTRACT:
SUBMITTER: Yan X
PROVIDER: S-EPMC7695372 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Yan Xinmiao X Yang Yiyan Y Chen Zikun Z Yin Zuojing Z Deng Zeliang Z Qiu Tianyi T Tang Kailin K Cao Zhiwei Z
Aging 20201110 21
Though promising, identifying synergistic combinations from a large pool of candidate drugs remains challenging for cancer treatment. Due to unclear mechanism and limited confirmed cases, only a few computational algorithms are able to predict drug synergy. Yet they normally require the drug-cell treatment results as an essential input, thus exclude the possibility to pre-screen those unexplored drugs without cell treatment profiling. Based on the largest dataset of 33,574 combinational scenario ...[more]