Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC7478165 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Li Xingjian X Payne Daniel T DT Ampolu Badarinath B Bland Nicholas N Brown Jane T JT Dutton Mark J MJ Fitton Catherine A CA Gulliver Abigail A Hale Lee L Hamza Daniel D Jones Geraint G Lane Rebecca R Leach Andrew G AG Male Louise L Merisor Elena G EG Morton Michael J MJ Quy Alex S AS Roberts Ruth R Scarll Rosanna R Schulz-Utermoehl Timothy T Stankovic Tatjana T Stevenson Brett B Fossey John S JS Agathanggelou Angelo A
MedChemComm 20190801 8
Parthenolide is a natural product that exhibits anti-leukaemic activity, however, its clinical use is limited by its poor bioavailability. It may be extracted from <i>feverfew</i> and protocols for growing, extracting and derivatising it are reported<i>.</i> A novel parthenolide derivative with good bioavailability and pharmacological properties was identified through a screening cascade based on <i>in vitro</i> anti-leukaemic activity and calculated "drug-likeness" properties, <i>in vitro</i> a ...[more]