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Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

ABSTRACT: Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basic and clinical research on developing alternative anticancer therapies.

SUBMITTER: Talib WH

PROVIDER: S-EPMC7696819 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Talib Wamidh H WH Alsalahat Izzeddin I Daoud Safa S Abutayeh Reem Fawaz RF Mahmod Asma Ismail AI

Molecules (Basel, Switzerland) 20201114 22

Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies cov ...[more]

PMID: 33202681

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