Ontology highlight
ABSTRACT:
SUBMITTER: Kawauchi K
PROVIDER: S-EPMC7697063 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Kawauchi Keiko K Urano Ryoto R Kinoshita Natsuki N Kuwamoto Shin S Torii Takeru T Hashimoto Yoshiki Y Taniguchi Shinya S Tsuruta Mitsuki M Miyoshi Daisuke D
Genes 20201112 11
G-quadruplex (G4) is the non-canonical secondary structure of DNA and RNA formed by guanine-rich sequences. G4-forming sequences are abundantly located in telomeric regions and in the promoter and untranslated regions (UTR) of cancer-related genes, such as <i>RAS</i> and <i>MYC</i>. Extensive research has suggested that G4 is a potential molecular target for cancer therapy. Here, we reviewed G4 ligands as photosensitizers for cancer photodynamic therapy (PDT), which is a minimally invasive thera ...[more]