Ontology highlight
ABSTRACT:
SUBMITTER: Jin S
PROVIDER: S-EPMC7698041 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Jin Songhee S Jang Jisun J Lee Soyeon S Kim Il Won IW
Pharmaceutics 20201116 11
Pharmaceutical eutectics are solid mixtures, where the crystals of active pharmaceutical ingredients (APIs) are finely divided in the phase-separated microstructures. The size reduction makes the eutectic formation a viable option to improve the dissolution rate of the poorly soluble APIs. In the present study, ibuprofen, naproxen, and sorafenib were investigated in terms of their phase behaviors with fatty alcohols, such as tetradecanol, octadecanol, and docosanol. Among the studied APIs, only ...[more]