Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC7704101 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Chen Jian J Mitra Abhisek A Li Shulin S Song Shumei S Nguyen Bao-Ngoc BN Chen Jiun-Sheng JS Shin Ji-Hyun JH Gough Nancy R NR Lin Paul P Obias Vincent V He Aiwu Ruth AR Yao Zhixing Z Malta Tathiane M TM Noushmehr Houtan H Latham Patricia S PS Su Xiaoping X Rashid Asif A Mishra Bibhuti B Wu Ray-Chang RC Mishra Lopa L
Cancer research 20200303 9
RING-finger E3 ligases are instrumental in the regulation of inflammatory cascades, apoptosis, and cancer. However, their roles are relatively unknown in TGFβ/SMAD signaling. SMAD3 and its adaptors, such as β2SP, are important mediators of TGFβ signaling and regulate gene expression to suppress stem cell-like phenotypes in diverse cancers, including hepatocellular carcinoma (HCC). Here, PJA1, an E3 ligase, promoted ubiquitination and degradation of phosphorylated SMAD3 and impaired a SMAD3/β2SP- ...[more]