Ontology highlight
ABSTRACT:
SUBMITTER: Mackenzie JS
PROVIDER: S-EPMC7705017 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Nature communications 20201130 1
The approval of bedaquiline (BDQ) for the treatment of tuberculosis has generated substantial interest in inhibiting energy metabolism as a therapeutic paradigm. However, it is not known precisely how BDQ triggers cell death in Mycobacterium tuberculosis (Mtb). Using <sup>13</sup>C isotopomer analysis, we show that BDQ-treated Mtb redirects central carbon metabolism to induce a metabolically vulnerable state susceptible to genetic disruption of glycolysis and gluconeogenesis. Metabolic flux prof ...[more]