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All are Equal, Some are More Equal: Targeting IL 12 and 23 in IBD - A Clinical Perspective.

ABSTRACT: Chronic inflammatory diseases like inflammatory bowel diseases (IBD) or psoriasis represents a worldwide health burden. Researchers provided great achievements in understanding the origin of these diseases leading to improved therapeutic options. The discovery of cytokines like tumor necrosis factor-? or transforming growth factor-? are examples for these efforts. Interleukin 12 (IL 12) and interleukin 23 (IL 23) represent different important cytokines in this regard. They both belong to the interleukin 12 family and are related by sharing the subunit p40. Ustekinumab is an antibody that blocks p40 and thereby interleukins 12 and 23. Trials showed promising results in treating IBD patients with this drug. Consequently, new questions arose about the distinct features of IL 12 and 23. This review focuses on these interleukins regarding their functions in the healthy and inflamed gut and provides an overview about the results from in vitro and in vivo studies as well as clinical trials.

SUBMITTER: Jefremow A

PROVIDER: S-EPMC7705252 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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All are Equal, Some are More Equal: Targeting IL 12 and 23 in IBD - A Clinical Perspective.

Jefremow André A Neurath Markus F MF

ImmunoTargets and therapy 20201126

Chronic inflammatory diseases like inflammatory bowel diseases (IBD) or psoriasis represents a worldwide health burden. Researchers provided great achievements in understanding the origin of these diseases leading to improved therapeutic options. The discovery of cytokines like tumor necrosis factor-α or transforming growth factor-β are examples for these efforts. Interleukin 12 (IL 12) and interleukin 23 (IL 23) represent different important cytokines in this regard. They both belong to the int ...[more]

PMID: 33274187

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What Can IBD Specialists Learn from IL-23 Trials in Dermatology?

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| S-EPMC9097670 | biostudies-literature

IL-12 and IL-23/Th17 axis in systemic lupus erythematosus.

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| S-EPMC6362534 | biostudies-literature

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| S-EPMC6380365 | biostudies-literature

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Project description:Cytokines of the IL-12 family show structural similarities but have distinct functions in the immune system. Prominent members of this cytokine family are the pro-inflammatory cytokines IL-12 and IL-23. These two cytokines share cytokine subunits and receptor chains but have different functions in autoimmune diseases, cancer and infections. Accordingly, structural knowledge about receptor complex formation is essential for the development of new therapeutic strategies preventing and/or inhibiting cytokine:receptor interaction. In addition, intracellular signaling cascades can be targeted to inhibit cytokine-mediated effects. Single nucleotide polymorphisms can lead to alteration in the amino acid sequence and thereby influencing protein functions or protein-protein interactions. To understand the biology of IL-12 and IL-23 and to establish efficient targeting strategies structural knowledge about cytokines and respective receptors is crucial. A highly efficient therapy might be a combination of different drugs targeting extracellular cytokine:receptor assembly and intracellular signaling pathways.

| S-EPMC7600943 | biostudies-literature

IL-12-polarized Th1 cells produce GM-CSF and induce EAE independent of IL-23.

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