Ontology highlight
ABSTRACT:
SUBMITTER: Kuhn NF
PROVIDER: S-EPMC7710757 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Kuhn Nicholas F NF Lopez Andrea V AV Li Xinghuo X Cai Winson W Daniyan Anthony F AF Brentjens Renier J RJ
Nature communications 20201202 1
While effective in specific settings, adoptive chimeric antigen receptor (CAR) T cell therapy for cancer requires further improvement and optimization. Our previous results show that CD40L-overexpressing CAR T cells mobilize endogenous immune effectors, resulting in improved antitumor immunity. However, the cell populations required for this protective effect remain to be identified. Here we show, by analyzing Batf3<sup>-/-</sup> mice lacking the CD103<sup>+</sup> conventional dendritic cell typ ...[more]