Ontology highlight
ABSTRACT:
SUBMITTER: Komuro A
PROVIDER: S-EPMC7720272 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Biochemical and biophysical research communications 20161013 2
LGP2 and MDA5 cooperate to detect viral RNA in the cytoplasm of Picornavirus-infected cells and activate innate immune responses. To further define regulatory components of RNA recognition by LGP2/MDA5, a yeast two-hybrid screen was used to identify LGP2-interacting proteins. The screening has identified the TAR-RNA binding protein (TRBP), which is known to be an essential factor for RNA interference (RNAi). Immuno-precipitation experiments demonstrated that TRBP interacted specifically with LGP ...[more]