Ontology highlight
ABSTRACT:
SUBMITTER: Albanese A
PROVIDER: S-EPMC7723053 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Albanese Alexandre A Swaney Justin M JM Yun Dae Hee DH Evans Nicholas B NB Antonucci Jenna M JM Velasco Silvia S Sohn Chang Ho CH Arlotta Paola P Gehrke Lee L Chung Kwanghun K
Scientific reports 20201208 1
Brain organoids grown from human pluripotent stem cells self-organize into cytoarchitectures resembling the developing human brain. These three-dimensional models offer an unprecedented opportunity to study human brain development and dysfunction. Characterization currently sacrifices spatial information for single-cell or histological analysis leaving whole-tissue analysis mostly unexplored. Here, we present the SCOUT pipeline for automated multiscale comparative analysis of intact cerebral org ...[more]