Ontology highlight
ABSTRACT:
SUBMITTER: Hodkinson BP
PROVIDER: S-EPMC7723809 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Hodkinson Brendan P BP Schaffer Michael M Brody Joshua D JD Jurczak Wojciech W Carpio Cecilia C Ben-Yehuda Dina D Avivi Irit I Forslund Ann A Özcan Muhit M Alvarez John J Ceulemans Rob R Fourneau Nele N Younes Anas A Balasubramanian Sriram S
Translational oncology 20201206 1
We analyzed potential biomarkers of response to ibrutinib plus nivolumab in biopsies from patients with diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and Richter's transformation (RT) from the LYM1002 phase I/IIa study, using programmed death ligand 1 (PD-L1) immunohistochemistry, whole exome sequencing (WES), and gene expression profiling (GEP). In DLBCL, PD-L1 elevation was more frequent in responders versus nonresponders (5/8 [62.5%] vs. 3/16 [18.8%]; p = 0.065; complete re ...[more]