Ontology highlight
ABSTRACT:
SUBMITTER: Mishra A
PROVIDER: S-EPMC7724165 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Mishra Aarti A Shang Yuan Y Wang Yiwei Y Bacon Eliza R ER Yin Fei F Brinton Roberta D RD
iScience 20201120 12
Aging and endocrine transition states can significantly impact inflammation across organ systems. Neuroinflammation is well documented in Alzheimer disease (AD). Herein, we investigated neuroinflammation that emerges during mid-life aging, chronological and endocrinological, in the female brain as an early initiating mechanism driving AD risk later in life. Analyses were conducted in a translational rodent model of mid-life chronological and endocrinological aging followed by validation in trans ...[more]