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CAR T cells for other pediatric non-B-cell hematologic malignancies.

ABSTRACT: As CAR T-cell therapy has advanced in B-cell acute lymphoblastic leukemia, research is now underway to develop similar therapies for other lymphoid and myeloid malignancies for pediatric patients. Barriers, including antigen selection and on-target/off-tumor toxicity, have prevented the rapid development of immune-based therapies for T-lineage and myeloid malignancies. More recently, unique strategies have been developed to overcome these barriers, with several products advancing to clinical trials. For T-lineage diseases, targets have focused on CD5, CD7, and CD38, whereas myeloid disease targets have predominately focused on CD123, CD33, and, more recently, CLL-1. This review provides a comprehensive overview of these targets and approaches to overcoming safety concerns in the development of CAR T-cell therapies for pediatric patients with T-lineage and myeloid malignancies.

SUBMITTER: Lamble AJ

PROVIDER: S-EPMC7727568 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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CAR T cells for other pediatric non-B-cell hematologic malignancies.

Lamble Adam J AJ Gardner Rebecca R

Hematology. American Society of Hematology. Education Program 20201201 1

As CAR T-cell therapy has advanced in B-cell acute lymphoblastic leukemia, research is now underway to develop similar therapies for other lymphoid and myeloid malignancies for pediatric patients. Barriers, including antigen selection and on-target/off-tumor toxicity, have prevented the rapid development of immune-based therapies for T-lineage and myeloid malignancies. More recently, unique strategies have been developed to overcome these barriers, with several products advancing to clinical tri ...[more]

PMID: 33275678

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