Ontology highlight
ABSTRACT:
SUBMITTER: Mitchell RE
PROVIDER: S-EPMC7728259 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Mitchell Ruth E RE Bates Kirsty K Wootton Robyn E RE Harroud Adil A Richards J Brent JB Davey Smith George G Munafò Marcus R MR
PLoS biology 20201130 11
The causes of multiple sclerosis (MS) remain unknown. Smoking has been associated with MS in observational studies and is often thought of as an environmental risk factor. We used two-sample Mendelian randomization (MR) to examine whether this association is causal using genetic variants identified in genome-wide association studies (GWASs) as associated with smoking. We assessed both smoking initiation and lifetime smoking behaviour (which captures smoking duration, heaviness, and cessation). T ...[more]