Ontology highlight
ABSTRACT:
SUBMITTER: LeBlond ND
PROVIDER: S-EPMC7730064 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
LeBlond Nicholas D ND Nunes Julia R C JRC Smith Tyler K T TKT O'Dwyer Conor C Robichaud Sabrina S Gadde Suresh S Côté Marceline M Kemp Bruce E BE Ouimet Mireille M Fullerton Morgan D MD
International journal of molecular sciences 20201127 23
The dysregulation of macrophage lipid metabolism drives atherosclerosis. AMP-activated protein kinase (AMPK) is a master regulator of cellular energetics and plays essential roles regulating macrophage lipid dynamics. Here, we investigated the consequences of atherogenic lipoprotein-induced foam cell formation on downstream immunometabolic signaling in primary mouse macrophages. A variety of atherogenic low-density lipoproteins (acetylated, oxidized, and aggregated forms) activated AMPK signalin ...[more]