Ontology highlight
ABSTRACT:
SUBMITTER: Ouwendijk WJD
PROVIDER: S-EPMC7730162 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Ouwendijk Werner J D WJD Depledge Daniel P DP Rajbhandari Labchan L Lenac Rovis Tihana T Jonjic Stipan S Breuer Judith J Venkatesan Arun A Verjans Georges M G M GMGM Sadaoka Tomohiko T
Nature communications 20201210 1
Varicella-zoster virus (VZV) establishes lifelong neuronal latency in most humans world-wide, reactivating in one-third to cause herpes zoster and occasionally chronic pain. How VZV establishes, maintains and reactivates from latency is largely unknown. VZV transcription during latency is restricted to the latency-associated transcript (VLT) and RNA 63 (encoding ORF63) in naturally VZV-infected human trigeminal ganglia (TG). While significantly more abundant, VLT levels positively correlated wit ...[more]