Ontology highlight
ABSTRACT:
SUBMITTER: Miyagi M
PROVIDER: S-EPMC7746184 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Miyagi Masaru M Wilson Rachel R Saigusa Daisuke D Umeda Keiko K Saijo Reina R Hager Christopher L CL Li Yuejin Y McCormick Thomas T Ghannoum Mahmoud A MA
PloS one 20201217 12
We previously found that the elevated abundance of the fungus Candida tropicalis is positively correlated with the bacteria Escherichia coli and Serratia marcescens in Crohn's disease patients and the three pathogens, when co-cultured, form a robust mixed-species biofilm. The finding suggests that these three pathogens communicate and promote biofilm formation, possibly through secretion of small signaling molecules. To identify candidate signaling molecules, we carried out a metabolomic analysi ...[more]