Dataset Information

Plasma BCAA concentrations during exercise of varied intensities in young healthy men-the impact of endurance training.

ABSTRACT:

Background

Branched-chain amino acids (BCAA) i.e., leucine (Leu), isoleucine (Ile) and valine (Val) are important amino acids, which metabolism play a role in maintaining system energy homeostasis at rest and during exercise. As recently shown lowering of circulating BCAA level improves insulin sensitivity and cardiac metabolic health. However, little is known concerning the impact of a single bout of incremental exercise and physical training on the changes in blood BCAA. The present study aimed to determine the impact of a gradually increasing exercise intensity-up to maximal oxygen uptake (VO_2max) on the changes of the plasma BCAA [?BCAA]_pl, before and after 5-weeks of moderate-intensity endurance training (ET).

Methods

Ten healthy young, untrained men performed an incremental cycling exercise test up to exhaustion to reach VO_2max, before and after ET.

Results

We have found that exercise of low-to-moderate intensity (up to ?50% of VO_2max lasting about 12 min) had no significant effect on the [?BCAA]_pl, however the exercise of higher intensity (above 70% of VO_2max lasting about 10 min) resulted in a pronounced decrease (p < 0.05) in [?BCAA]_pl. The lowering of plasma BCAA when performing exercise of higher intensity was preceded by a significant increase in plasma lactate concentration, showing that a significant attenuation of BCAA during incremental exercise coincides with exercise-induced acceleration of glycogen utilization. In addition, endurance training, which significantly increased power generating capabilities at VO_2max (p = 0.004) had no significant impact on the changes of [?BCAA]_pl during this incremental exercise.

Conclusion

We have concluded that an exercise of moderate intensity of relatively short duration generally has no effect on the [?BCAA]_pl in young, healthy men, whereas significant decrease in [?BCAA]_pl occurs when performing exercise in heavy-intensity domain. The impact of exercise intensity on the plasma BCAA concentration seems to be especially important for patients with cardiometabolic risk undertaken cardiac rehabilitation or recreational activity.

SUBMITTER: Gawedzka A

PROVIDER: S-EPMC7759138 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Plasma BCAA concentrations during exercise of varied intensities in young healthy men-the impact of endurance training.

Gawedzka Anna A Grandys Marcin M Duda Krzysztof K Zapart-Bukowska Justyna J Zoladz Jerzy A JA Majerczak Joanna J

PeerJ 20201221

<h4>Background</h4>Branched-chain amino acids (BCAA) i.e., leucine (Leu), isoleucine (Ile) and valine (Val) are important amino acids, which metabolism play a role in maintaining system energy homeostasis at rest and during exercise. As recently shown lowering of circulating BCAA level improves insulin sensitivity and cardiac metabolic health. However, little is known concerning the impact of a single bout of incremental exercise and physical training on the changes in blood BCAA. The present st ...[more]

PMID: 33391874

Similar Datasets

Project description:UnlabelledRegular exercise training improves maximal oxygen uptake (VO2max), but the optimal intensity and volume necessary to obtain maximal benefit remains to be defined. A growing body of evidence suggests that exercise training with low-volume but high-intensity may be a time-efficient means to achieve health benefits. In the present study, we measured changes in VO2max and traditional cardiovascular risk factors after a 10 wk. training protocol that involved three weekly high-intensity interval sessions. One group followed a protocol which consisted of 4×4 min at 90% of maximal heart rate (HRmax) interspersed with 3 min active recovery at 70% HRmax (4-AIT), the other group performed a single bout protocol that consisted of 1×4 min at 90% HRmax (1-AIT). Twenty-six inactive but otherwise healthy overweight men (BMI: 25-30, age: 35-45 y) were randomized to either 1-AIT (n = 11) or 4-AIT (n = 13). After training, VO2max increased by 10% (∼5.0 mL⋅kg(-1)⋅min(-1)) and 13% (∼6.5 mL⋅kg(-1)⋅min(-1)) after 1-AIT and 4-AIT, respectively (group difference, p = 0.08). Oxygen cost during running at a sub-maximal workload was reduced by 14% and 13% after 1-AIT and 4-AIT, respectively. Systolic blood pressure decreased by 7.1 and 2.6 mmHg after 1-AIT and 4-AIT respectively, while diastolic pressure decreased by 7.7 and 6.1 mmHg (group difference, p = 0.84). Both groups had a similar ∼5% decrease in fasting glucose. Body fat, total cholesterol, LDL-cholesterol, and ox-LDL cholesterol only were significantly reduced after 4-AIT. Our data suggest that a single bout of AIT performed three times per week may be a time-efficient strategy to improve VO2max and reduce blood pressure and fasting glucose in previously inactive but otherwise healthy middle-aged individuals. The 1-AIT type of exercise training may be readily implemented as part of activities of daily living and could easily be translated into programs designed to improve public health.Trial registrationClinicalTrials.govNCT00839579.

Dataset Information

Plasma BCAA concentrations during exercise of varied intensities in young healthy men-the impact of endurance training.

Background

Methods

Results

Conclusion

Publications

Plasma BCAA concentrations during exercise of varied intensities in young healthy men-the impact of endurance training.

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