The Genetic Complexity of Prostate Cancer.
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ABSTRACT:
SUBMITTER: Comperat E
PROVIDER: S-EPMC7760266 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
The Genetic Complexity of Prostate Cancer.
Compérat Eva E Wasinger Gabriel G Oszwald André A Kain Renate R Cancel-Tassin Geraldine G Cussenot Olivier O
Genes 20201125 12
Prostate cancer (PCa) is a major concern in public health, with many genetically distinct subsets. Genomic alterations in PCa are extraordinarily complex, and both germline and somatic mutations are of great importance in the development of this tumor. The aim of this review is to provide an overview of genetic changes that can occur in the development of PCa and their role in potential therapeutic approaches. Various pathways and mechanisms proposed to play major roles in PCa are described in d ...[more]
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