Ontology highlight
ABSTRACT:
SUBMITTER: Shalaby R
PROVIDER: S-EPMC7762061 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Biomolecules 20201204 12
BOK is an evolutionarily conserved BCL-2 family member that resembles the apoptotic effectors BAK and BAX in sequence and structure. Based on these similarities, BOK has traditionally been classified as a BAX-like pro-apoptotic protein. However, the mechanism of action and cellular functions of BOK remains controversial. While some studies propose that BOK could replace BAK and BAX to elicit apoptosis, others attribute to this protein an indirect way of apoptosis regulation. Adding to the debate ...[more]