Ontology highlight
ABSTRACT:
SUBMITTER: Lin Y
PROVIDER: S-EPMC7762435 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Lin Yan Y He Ziqin Z Ye Jiazhou J Liu Ziyu Z She Xiaomin X Gao Xing X Liang Rong R
OncoTargets and therapy 20201221
As a pleiotropic cytokine, interleukin-6 (IL-6) not only regulates the cellular immune response, but it also promotes tumor development by activating multiple carcinogenic pathways. IL-6 expression is significantly elevated in colorectal cancer (CRC) and is closely related to CRC development and patient prognosis. In CRC, IL-6 activates signal transducers and activators of transduction-3 (STAT3) to promote tumor initiation and tumor growth. IL-6/STAT3 signalling has a profound effect on tumor-in ...[more]