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Progress in Understanding the IL-6/STAT3 Pathway in Colorectal Cancer.


ABSTRACT: As a pleiotropic cytokine, interleukin-6 (IL-6) not only regulates the cellular immune response, but it also promotes tumor development by activating multiple carcinogenic pathways. IL-6 expression is significantly elevated in colorectal cancer (CRC) and is closely related to CRC development and patient prognosis. In CRC, IL-6 activates signal transducers and activators of transduction-3 (STAT3) to promote tumor initiation and tumor growth. IL-6/STAT3 signalling has a profound effect on tumor-infiltrating immune cells in the tumor immune microenvironment in CRC. Additionally, IL-6/STAT3 pathway activates downstream target genes to protect tumor cells from apoptosis; drive tumor cell proliferation, cell cycle progression, invasion and metastasis; promote tumor angiogenesis; and stimulate drug resistance. Therefore, a thorough understanding of the many effects of the IL-6/STAT3 pathway in CRC is needed, which the present review examines.

SUBMITTER: Lin Y 

PROVIDER: S-EPMC7762435 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Progress in Understanding the IL-6/STAT3 Pathway in Colorectal Cancer.

Lin Yan Y   He Ziqin Z   Ye Jiazhou J   Liu Ziyu Z   She Xiaomin X   Gao Xing X   Liang Rong R  

OncoTargets and therapy 20201221


As a pleiotropic cytokine, interleukin-6 (IL-6) not only regulates the cellular immune response, but it also promotes tumor development by activating multiple carcinogenic pathways. IL-6 expression is significantly elevated in colorectal cancer (CRC) and is closely related to CRC development and patient prognosis. In CRC, IL-6 activates signal transducers and activators of transduction-3 (STAT3) to promote tumor initiation and tumor growth. IL-6/STAT3 signalling has a profound effect on tumor-in  ...[more]

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