Ontology highlight
ABSTRACT:
SUBMITTER: Ramsay RR
PROVIDER: S-EPMC7763263 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Ramsay Rona R RR Basile Livia L Maniquet Antonin A Hagenow Stefanie S Pappalardo Matteo M Saija Maria Chiara MC Bryant Sharon D SD Albreht Alen A Guccione Salvatore S
Molecules (Basel, Switzerland) 20201213 24
The irreversible inhibitors of monoamine oxidases (MAO) slow neurotransmitter metabolism in depression and neurodegenerative diseases. After oxidation by MAO, hydrazines, cyclopropylamines and propargylamines form a covalent adduct with the flavin cofactor. To assist the design of new compounds to combat neurodegeneration, we have updated the kinetic parameters defining the interaction of these established drugs with human MAO-A and MAO-B and analyzed the required features. The K<sub>i</sub> val ...[more]