Ontology highlight
ABSTRACT:
SUBMITTER: Albreht A
PROVIDER: S-EPMC5985292 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Albreht Alen A Vovk Irena I Mavri Janez J Marco-Contelles Jose J Ramsay Rona R RR
Frontiers in chemistry 20180528
Successful propargylamine drugs such as deprenyl inactivate monoamine oxidase (MAO), a target in multi-faceted approaches to prevent neurodegeneration in the aging population, but the chemical structure and mechanism of the irreversible inhibition are still debated. We characterized the covalent cyanine structure linking the multi-target propargylamine inhibitor ASS234 and the flavin adenine dinucleotide in MAO-A using a combination of ultra-high performance liquid chromatography, spectroscopy, ...[more]