Ontology highlight
ABSTRACT:
SUBMITTER: Lenza MP
PROVIDER: S-EPMC7765293 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Lenza María Pia MP Atxabal Unai U Oyenarte Iker I Jiménez-Barbero Jesús J Ereño-Orbea June J
Cells 20201215 12
The sialic acid-binding immunoglobulin-type of lectins (Siglecs) are receptors that recognize sialic acid-containing glycans. In the majority of the cases, Siglecs are expressed on immune cells and play a critical role in regulating immune cell signaling. Over the years, it has been shown that the sialic acid-Siglec axis participates in immunological homeostasis, and that any imbalance can trigger different pathologies, such as autoimmune diseases or cancer. For all this, different therapeutics ...[more]