Ontology highlight
ABSTRACT:
SUBMITTER: Youngblood BA
PROVIDER: S-EPMC7823959 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Youngblood Bradford A BA Leung John J Falahati Rustom R Williams Jason J Schanin Julia J Brock Emily C EC Singh Bhupinder B Chang Alan T AT O'Sullivan Jeremy A JA Schleimer Robert P RP Tomasevic Nenad N Bebbington Christopher R CR Bochner Bruce S BS
Cells 20201224 1
Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosinophils, and at low levels on basophils. These cells can participate in inflammatory responses by releasing mediators that attract or activate other cells, contributing to the pathogenesis of allergic and non-allergic diseases. Since its discovery in ...[more]