Dataset Information

Epidemiology of Functional Seizures Among Adults Treated at a University Hospital.

ABSTRACT:

Importance

Functional seizures (formerly psychogenic nonepileptic seizures), paroxysmal episodes that are often similar to epileptic seizures in their clinical presentation and display no aberrant brain electrical patterns, are understudied. Patients experience a long diagnostic delay, few treatment modalities, a high rate of comorbidities, and significant stigma due to the lack of knowledge about functional seizures.

Objective

To characterize the clinical epidemiology of a population of patients with functional seizures observed at Vanderbilt University Medical Center (VUMC).

Design, setting, and participants

This case-control study included patients with functional seizures identified in the VUMC electronic health record (VUMC-EHR) system from October 1989 to October 2018. Patients with epilepsy were excluded from the study and all remaining patients in the VUMC medical center system were used as controls. In total, the study included 1431 patients diagnosed with functional seizures, 2251 with epilepsy and functional seizures, 4715 with epilepsy without functional seizures, and 502?200 control patients who received treatment at VUMC for a minimum of a 3 years. Data were analyzed from November 2018 to March 2020.

Exposure

Diagnosis of functional seizures, as identified from the VUMC-EHR system by an automated phenotyping algorithm that incorporated International Classification of Diseases, Ninth Revision (ICD-9) codes, International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes, Current Procedural Terminology codes, and natural language processing.

Main outcomes and measures

Associations of functional seizures with comorbidities and risk factors, measured in odds ratios (ORs).

Results

Of 2?346?808 total patients in the VUMC-EHR aged 18 years or older, 3341 patients with functional seizures were identified (period prevalence, 0.14%), 1062 (74.2%) of whom were women and for which the median (interquartile range) age was 49.3 (39.4-59.9) years. This assessment replicated previously reported associations with psychiatric disorders including posttraumatic stress disorder (PTSD) (OR, 1.22; 95% CI, 1.21-1.24; P?Conclusions and relevanceThis case-control study found evidence to support previously reported associations, discovered new associations between functional seizures and PTSD, anxiety, and depression. An association between cerebrovascular disease and functional seizures was also found. Results suggested that sexual trauma may be a mediating factor in the association between female sex and functional seizures.

SUBMITTER: Goleva SB

PROVIDER: S-EPMC7772716 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Epidemiology of Functional Seizures Among Adults Treated at a University Hospital.

Goleva Slavina B SB Lake Allison M AM Torstenson Eric S ES Haas Kevin F KF Davis Lea K LK

JAMA network open 20201201 12

<h4>Importance</h4>Functional seizures (formerly psychogenic nonepileptic seizures), paroxysmal episodes that are often similar to epileptic seizures in their clinical presentation and display no aberrant brain electrical patterns, are understudied. Patients experience a long diagnostic delay, few treatment modalities, a high rate of comorbidities, and significant stigma due to the lack of knowledge about functional seizures.<h4>Objective</h4>To characterize the clinical epidemiology of a popula ...[more]

PMID: 33372972

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Dataset Information

Epidemiology of Functional Seizures Among Adults Treated at a University Hospital.

Importance

Objective

Design, setting, and participants

Exposure

Main outcomes and measures

Results

Publications

Epidemiology of Functional Seizures Among Adults Treated at a University Hospital.

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