Ontology highlight
ABSTRACT:
SUBMITTER: Garsi JB
PROVIDER: S-EPMC7784717 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Garsi Jean-Baptiste JB Vece Vito V Sernissi Lorenzo L Auger-Morin Catherine C Hanessian Stephen S McCracken Alison N AN Selwan Elizabeth E Ramirez Cuauhtemoc C Dahal Amogha A Romdhane Nadine Ben NB Finicle Brendan T BT Edinger Aimee L AL
Bioorganic & medicinal chemistry letters 20190719 18
Inspired by the cytotoxicity of perphenazine toward cancer cells and its ability to activate the serine/threonine protein phosphatase 2A (PP2A), we prepared series of ether-carbon linked analogs of a constrained synthetic sphingolipid analog 3, known for its cytotoxicity, nutrient transporter down-regulation and vacuolation properties, incorporating the tricyclic neuroleptics phenoxazine and phenothiazine to represent hybrid structures with possible synergistic cytotoxic activity. While the orig ...[more]