Ontology highlight
ABSTRACT:
SUBMITTER: Jia J
PROVIDER: S-EPMC7785494 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Jia Jingyue J Bissa Bhawana B Brecht Lukas L Allers Lee L Choi Seong Won SW Gu Yuexi Y Zbinden Mark M Burge Mark R MR Timmins Graham G Hallows Kenneth K Behrends Christian C Deretic Vojo V
Molecular cell 20200128 5
AMPK is a central regulator of metabolism and autophagy. Here we show how lysosomal damage activates AMPK. This occurs via a hitherto unrecognized signal transduction system whereby cytoplasmic sentinel lectins detect membrane damage leading to ubiquitination responses. Absence of Galectin 9 (Gal9) or loss of its capacity to recognize lumenal glycans exposed during lysosomal membrane damage abrogate such ubiquitination responses. Proteomic analyses with APEX2-Gal9 have revealed global changes wi ...[more]