Label-free proteomic analysis of serum exosomes from paroxysmal atrial fibrillation patients.

ABSTRACT:

Background

Atrial fibrillation (AF) is the most common cardiac heterogeneous rhythm disorder. It represents a major cause of mortality and morbidity, mainly related to embolic events and heart failure. Mechanisms of AF are complex and remain incompletely understood. Recent evidence suggests exosomes are membrane-coated objects released by many cell-types. Their presence in body fluids and the variable surface composition and content render them attractive as a mechanism for potential biomarkers. However, the content of serum exosomes of AF patients has not been fully delineated.

Methods

In this work, the serum exosomes from AF patients and healthy donors were used to compare changes in the exosome protein content. Exosomes were isolated from serum of AF patients and healthy

SUBMITTER: Ni H 

PROVIDER: S-EPMC7789314 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature