Ontology highlight
ABSTRACT:
SUBMITTER: Kaito S
PROVIDER: S-EPMC7793497 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Kaito Satoshi S Iwama Atsushi A
International journal of molecular sciences 20201223 1
Polycomb repressive complexes (PRCs) are epigenetic regulators that mediate repressive histone modifications. PRCs play a pivotal role in the maintenance of hematopoietic stem cells through repression of target genes involved in cell proliferation and differentiation. Next-generation sequencing technologies have revealed that various hematologic malignancies harbor mutations in PRC2 genes, such as <i>EZH2</i>, <i>EED</i>, and <i>SUZ12</i>, and PRC1.1 genes, such as <i>BCOR</i> and <i>BCORL1</i>. ...[more]