Ontology highlight
ABSTRACT:
SUBMITTER: Miller B
PROVIDER: S-EPMC7794290 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Miller Brendan B Silverstein Ana A Flores Melanie M Cao Kevin K Kumagai Hiroshi H Mehta Hemal H HH Yen Kelvin K Kim Su- Jeong SJ Cohen Pinchas P
Scientific reports 20210108 1
SARS-CoV-2 induces a muted innate immune response compared to other respiratory viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate immunity. Polypeptides encoded by open reading frames of SARS-CoV and SARS-CoV-2 have been shown to localize to mitochondria and disrupt Mitochondrial Antiviral Signaling (MAVS) protein signaling. Therefore, we hypothesized that SARS-CoV-2 would distinctly regulate the mitochondrial transcriptome. We analyzed multiple publicly ...[more]