Ontology highlight
ABSTRACT:
SUBMITTER: Danesin C
PROVIDER: S-EPMC7794431 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Danesin Cathy C Darche-Gabinaud Romain R Escalas Nathalie N Bouguetoch Vanessa V Cochard Philippe P Al Oustah Amir A Ohayon David D Glise Bruno B Soula Cathy C
Scientific reports 20210108 1
Sulf2a belongs to the Sulf family of extracellular sulfatases which selectively remove 6-O-sulfate groups from heparan sulfates, a critical regulation level for their role in modulating the activity of signalling molecules. Data presented here define Sulf2a as a novel player in the control of Sonic Hedgehog (Shh)-mediated cell type specification during spinal cord development. We show that Sulf2a depletion in zebrafish results in overproduction of V3 interneurons at the expense of motor neurons ...[more]