Ontology highlight
ABSTRACT:
SUBMITTER: Jaune E
PROVIDER: S-EPMC7801734 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Jaune Emilie E Cavazza Elisa E Ronco Cyril C Grytsai Oleksandr O Abbe Patricia P Tekaya Nedra N Zerhouni Marwa M Beranger Guillaume G Kaminski Lisa L Bost Frédéric F Gesson Maeva M Tulic Meri M Hofman Paul P Ballotti Robert R Passeron Thierry T Botton Thomas T Benhida Rachid R Rocchi Stéphane S
Cell death & disease 20210111 1
In the search of biguanide-derived molecules against melanoma, we have discovered and developed a series of bioactive products and identified the promising new compound CRO15. This molecule exerted anti-melanoma effects on cells lines and cells isolated from patients including the ones derived from tumors resistant to BRAF inhibitors. Moreover, CRO15 was able to decrease viability of cells lines from a broad range of cancer types. This compound acts by two distinct mechanisms. First by activatin ...[more]